In the multiple dose segment, 50 volunteers received 600 mg hypericum extract tid (twice the normal recommended dose) with a daily dose of 5.6 mg of total hypericin. I am 33 and grew up on the beach and never had this before in my life. 4. Does St John’s wort affect other medications St John’s wort is known to adversely interact with some medications. Glad to be back. "), and was taking up to an ounce of the Hypericum tincture (1:2, fresh plant) a day...a truly excessive amount (it's an Irish thing, y'know?). The species name “perforatum” refers to the fact that the leaves of the plant are “perforated” or appear to have tiny holes which can only be seen on close inspection. He broke out in hives that lasted nearly a month. Cattle can eat some St. John’s Wort, but large amounts can cause photosensitivity and “hypericism,” a condition that could cause dehydration and death in the worst case, although weight loss (and thus lower market value) are more common. Minimal erythema dose was determined five, 20, and 68 hours after irradiation. 9 Finally, a report suggests that regular use of St. John's wort might also increase the risk of sun-induced cataracts. She later worked in the direct sunlight, and soon had second degree burns, complete with blisters, whevever the sunlight fell on the gel-treated skin. Some scientists became concerned, however, about an under-appreciated side effect of St. John’s wort. All reactions resolved after discontinuation of therapy. [Reversible increase in photosensitivity to UV-B caused by St. John's wort extract]. Did you know that St John's wort can cause extreme photosensitivity in many people? Cattle can eat some St. John’s Wort, but large amounts can cause photosensitivity and “hypericism,” a condition that could cause dehydration and death in the worst case, although weight loss (and thus lower market value) are more common. Photosensitivity rarely is reported in St. John’s wort clinical trials; however, pale patients who burn easily may not realize they burn more easily. I know it has some drug interactions, luckily I am not taking any drugs so I did not find this to be a problem. St. John's Wort causes photosensitivity when ingested by livestock. Hypericin and pseudohypericin: Pharmacokinetics and effects on photosensitivity in humans. I guess I am too likely to take people as they are without a second thought; an old friend announced one day that Father Yod (...don't ask) had told him to stop smoking reefer. Have someone who can help you gauge your illness objectively (ha) or at least tell you if you've fallen off the fence. The founder is Peter Berg. However, with the more sensitive photometric measurement, an increase of the erythema index after treatment with hypericum oil could be detected. I would need a BIG study to convince me otherwise...or I would need to start getting negative feedback. So ideally...the Wort would take away the highs and lows and make the emotional rollercoaster of todays hectic society more even. St. John's wort may pass into breast milk and may cause unwanted effects in a nursing baby. New Scientist. A few hours after sunbathing she developed symptoms on her arms and legs (again confined to sun-exposed skin). I have to say, this herb helps me a lot, I can feel it working. There is really only one cause for St John’s wort poisoning and that cause is simply the ingestion of the plant by the horse. St. John's wort (Hypericum perforatum) is a tradional folk remedy that is used for the topical treatment of superficial wounds, scars and burns. I don't have all that much experience with bipolar and other mental disorders and Hypericum...although I believe that consistant dosages long term is the way to go.......and careful with self medication. Alternative Therapies in Women's Health Archives. Medications that cause sun sensitivity such as sulfa drugs and the anti-inflammatory medication piroxicam (Feldene) , as well as omeprazole (Prilosec) or lansoprazole (Prevacid) : Keep in mind that St. John's wort might have an additive effect. Secondary effects are my grist (am I mixing metaphors again??). "~ St. Joan’s/John's wort oil protects my skin from radiation damage. The study uses data from the FDA. Squueeezze that unopened flower bud...just a hint of yellow petals peaking so cautiously from its sepal safety...sqqqueeeezze and you will delight to find a drop of redness so strong as to dye the fingers. What is St. John’s Wort. As he related a year later, he took a fly-fishing vacation after the class, returning to a place in the San Juans of Colorado (8,500 feet) that the class had visited. Although St. John’s wort needs a fair bit of light to thrive, it does best in partial sun. The popular herbal therapy is often used to ease symptoms of depression. A 35-year-old woman who took St. John’s wort (ground whole herb, 500 mg/d) for mild depression developed subacute polyneuropathy after sun exposure.3 One month after starting St. John’s wort, the patient developed stinging pain in sun-exposed areas, including the face and hands; she noted mild pain that appeared to be worsened by sun exposure. Insomnia 11. A. Maximum total hypericin plasma concentrations were observed about four hours after drug administration, and were 0, 28, 61, and 159 mcg/mL, respectively. I have to say, this herb helps me a lot, I can feel it working. I am shocked and alarmed...I spend many waking hours trying to find any new age cliches in my psychic body and gouging them out with a rusty Democles' sword. Photosensitivity reactions: Three cases of photosensitivity reactions occurred in individuals who used topical and/or oral St. John’s wort preparations prior … I have retailed and wholesaled herbs for 20 years and have taught and written about green stuff for 16 years (...and breathed and micturated for almost 54), and I have only run across 1 person to have shown signs of photosensitization from Hypericum. Ann Int Med 1999;130:510-514. Subject: Re: Bioregionalism, >I am shocked and alarmed...I spend many waking hours trying to find any new age cliches in my psychic body and gouging them out with a rusty Democles'. Photosensitivity reactions: Three cases of photosensitivity reactions occurred in individuals who used topical and/or oral St. John’s wort preparations prior to sun exposure or undergoing phototherapy . St. John’s Wort Tea Side Effects. Drug interactions are reported among people who take Lamictal and St. john's wort. In order to avoid this, it is important that patients avoid direct sun exposure when possible. 6. Dillon J. UV-B as a pro-aging and pro-cataract factor. 94-101. Secondary photosensitisation occurs in animals with liver damage. St. John's wort may affect fertility (your ability to have children). Answer: Photosensitization is unusual when it comes to St. John’s Wort. Rational Phytotherapy: A Physician’s Guide to Herbal Medicine. 15. St. John’s wort can also be used externally to help skin problems. Henriette's herbal is one of the oldest and largest herbal medicine sites on the net. Vandenbogaerde AL, et al. Intravenous administration of high-dose hypericin results in severe phototoxicity that precludes its clinical use. Probably worth avoiding if you're already photosensitive; otherwise it seems to be rare and reasonably mild in its consequences. Schempp CM, et al. 17. The authors conclude that the results confirm a phototoxic effect of hypericin on human keratinocytes, but note that blood levels achieved with normal therapeutic use would be too low to induce phototoxic skin reactions. E. Synergy with antidepressant meds (that he declined to identify). Phase I studies of hypericin, the active compound in St. John’s wort, as an antiretroviral agent in HIV-infected adults. Hello! Photosensitivity. 2000 Mar 20;172(6):302. This has been demonstrated in a randomized, placebo-controlled trial in which fair-skinned subjects who burned easily were given metered doses of hypericum extract (LI 160) and were exposed to UVA and UVB irradiation.4 Hypericin and pseudohypericin plasma concentrations also were monitored. St John's wort also decreases the levels of estrogens, such as estradiol, by accelerating its metabolism, and should not be taken by women on contraceptive pills. do-WOP! 1121-1122. Hautartz 1997;48:249-262. 5. But those who wish for an herbal nectar of delight of greater strength...they sit for hours collecting just flower petals in some zen like quest. Now I haven't asked any albinos doing truckloads of hypericum a day....maybe they'd have a problem. Schempp et al also studied the effects of topical application of hypericum oil (hypericin 110 mcg/mL) and hypericum ointment (hypericin 30 mcg/mL) on skin sensitivity to solar simulated radiation.17 Sixteen volunteers received either oil (n = 8) or ointment (n = 8). One doctor at the conference who treats a lot of AIDs patients said she had seen frequent cases of phototoxocity in dark skinned Puerto Ricans, especially with higher doses and long term administration. The species name “perforatum” refers to the fact that the leaves of the plant are “perforated” or appear to have tiny holes which can only be seen on close inspection. If you are pregnant, breastfeeding, trying to conceive, or you are taking oral contraceptives, it's important to talk with your doctor before taking St. John's wort. Sometimes folks break into mimicking the words, "social, historical, ecological, and economic," just as I now see people mimick, "body, mind, spirit," and "physical, mental, psychological, spiritual, and social." and H. formosum which we gathered during a couple of field trips. Without exposure to sunlight....the herbs anti-viral effect dropped markedly. Pp. Use has persisted in spite of later discovery that it doesn't help HIV in humans. And this even tempered plant grows in disturbed places...roadsides, lots, loves it when its been bulldozed a year or so ago. This may be an example of assumptive jumping from mammalian lab results to humans. A characteristic metabolite of St. John's wort is the photodynamic active plant pigment hypericin. 12. Anxiety 3. 2.4.1 St. John's Wort (Hypericum) and photosensitivity Here's the question (on the herblist (see 8.1.1 below) in November 1994): >As to Hypericum perforatum (St. John's Wort) causing photosensitivity in humans, I have been unable to find a single study that verifies this in vivo. I have not heard of one case of human photosensitivity...even in the blond, blue-eyed, fair skinned ones...from standard dosages of tinture. St. John’s wort can increase the rapid breakdown of irinotecan (Camptosar) by the body and decrease the efficacy of irinotecan (Camptosar). Schempp CM, et al. Direct photosensitisation occurs when the chemical comes from a defect in the animals metabolism of its red blood cells, or, more commonly, from plants such as St. John’s wort. Golsch S, Vocks E, Rakoski J, et al. 9 Finally, a report suggests that regular use of St. John's wort might also increase the risk of sun-induced cataracts. The authors suggest that this may provide a rationale for the traditional treatment of inflammatory skin disorders with hypericum extracts. Berg came up with the term in the seventies, no? I don't know about clinical studies...but in my experience the Wort works for some and not others for simple depression and light rollercoaster rides that do not incapacitate the riders. 7. You should not use this product if you are trying to get pregnant. 218-221. The student was using high quantities along with medication and the customer showed little more than passing and perhaps serendipitous symptoms, and I have had GALLONS of my Hypericum tincture and oil go through my grubbies over a couple of decades (usually used by folks going through a stretch of somato-psychic flakiness and often manifesting a peculiar, if temporary, lack of judgement regarding emotions, dosages, and self-monitoring). I'm a healthy female that has been on St John's Wort for 2 weeks now. If you wish to pursue this depressing subject further, start with the excellent newsletter, RACHEL'S ENVIRONMENTAL & HEALTH WEEKLY, put out on the net weekly by the Environmental Research Foundation, available from , or , and the WWW site: . Studies of sheep experimentally poisoned with Hypericum perforatum. I have found that they have really helped, not so anxious, no panic attacks, feel brighter and my RLS is only a few days a month now. Well, the way I hear it, old Dr. Kent had retired to practice in Montana and one day this basque sheepherder came into his office...) I have always tried my best to keep track of potential side-effects of herbs. Headache 9. I can't work on Susun Weed's precepts level, that the body takes what it needs from what you offer it, anymore than I can work with a phytopharmaceutical model that ignores the multi-systemic effects of a plant while focusing only on a specific band of pharmacokinetics...better even (they say) to refine (reduce) DOWN to single constituents so as to better exaggerate the band and diminish the "unwanted" whispers. See, for example: Mills, Stephanie. Now when I teach my students about this Wort...we general use flower buds and the stems and small leaves attached to them to prepare oils and tinctures. Emilyfarnsbarns Tue 01-Aug-17 11:34:23. Though this is a solid dosage, this supplement is hurt by the presence of a lot of fillers and additives that you won’t find in other competitors. 8. If you have a condition or are taking medication that increases your skin's sensitivity to sunlight, talk with your doctor to weigh the risks. Internally using large amounts of hypericin, an isolated constituent of St. John’s wort, increases the likelihood of experiencing photosensitivity. I was born the year WWII began, and spent the first several decades in a world of fewer and less "ripened" eco-toxins and ate food with fewer chemicals and fewer "recombinants". No change was apparent in visual erythema score after application of either hypericum oil or ointment. These folks do Bioregional Congresses, a newsletter called *Raise the Stakes*, creative performances, research, bioregional and deep ecology workshops, etc. 13. In pharmacy school we were told to counsel St John's Wort patients to wear sun cream pretty much all the time. In a single-dose segment, 13 volunteers received placebo or a standardized hypericum extract (900, 1,800 or 3,600 mg, containing 0, 2.8, 5.6, and 11.3 mg of total hypericins [sum of hypericin and pseudohypericin]) in a double-blind, crossover design. Although it seems to be well-tolerated when taken alone, St. John's wort has been shown to cause important drug interactions with several medications by interfering with drug metabolism pathways. In fact, I fashioned my entire B.S. He was what my grandma used to call "Black Irish" (I guess as opposed to a Dirty-Blond Irish like myself) and had the semi-transparent skin and jet-black hair of people like Liam or Patrick Clancy. But in my eyes it seems to have an affinity for the nerves...........and it seems to be specific for injuries accompanyed by nerve trauma.....like I cut my arm and my finger goes numb. The Brockmoller et al study in fair-skinned individuals showed that plasma levels of total hypericins (44 ng/mL)4 not far above therapeutic levels (14 ng/mL)6 can increase sensitivity to artificial UV irradiation by approximately 21% (intensities approximately three times higher than average daily exposure in Miami, FL).10. 11. St John’s wort may also impact on the breakdown of other drugs by Despite the benefits, some of the potential side effects of this herbal tea include photosensitivity, complications with surgery, and issues for pregnant and breastfeeding women.. Photosensitivity: Some people have reported increased photosensitivity when consuming this tea; if you feel like your eyes are extra sensitive to sunlight, stop drinking this tea. Six weeks later we could still see the shadow on the back of the leg where the sunlight didn't fall, and the shadow of a sandle strap across the front of the ankle. Disturbing, but true. Interesting idea though...to increase effectiveness I presume. 1. Look again-I am a bioregionalist, myself. In summer, many sheep suffered from inflammatory skin conditions around the ears, the eyes, and the bridge of the nose.1. That St John ’ s wort and olive oil can also be used externally to skin... 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